• Corpus ID: 55804872

A Systematic Review of Multimodal Treatment for 1 to 4 Brain Metastases

  title={A Systematic Review of Multimodal Treatment for 1 to 4 Brain Metastases},
  author={Joel Caballero Garc{\'i}a and Orlando Cruz Garc{\'i}a and Oscar Antonio Casanella Saint-Blancard and Rogelio D{\'i}az Moreno},
Treatment of brain metastases are controversial, being the optimal therapeutic combination still unknown. The aim of the present work was to determine the outcome differences among Whole Brain Radiation Therapy, Stereotactic Radiosurgery and Surgical Resection in terms of Overall Survival, Functional Independence, Local Control, Neurological Death and Neurocognitive Impairment. A systematically review of the pertinent literature was performed by using the Cochrane Register of Controlled Trials… 

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Current Treatment Strategies for Brain Metastasis and Complications From Therapeutic Techniques: A Review of Current Literature
The use of WBRT, radiosurgery, and resection for the treatment of brain metastases, and the use of radiation sensitizers and blood–brain barrier penetrating cytotoxics such as temozolomide are reviewed.
Treatment of single brain metastasis: Radiotherapy alone or combined with neurosurgery
It is coclude that patients with single brain metastasis and stable extracranial tumor activity should be treated with surgical excision and radiotherapy, and that radiotherapy alone appears to be sufficient.
The choice of treatment of single brain metastasis should be based on extracranial tumor activity and age.
Microsurgery plus whole brain irradiation versus Gamma Knife surgery alone for treatment of single metastases to the brain: a randomized controlled multicentre phase III trial
In patients harboring a single, small-sized metastasis, Gamma Knife surgery alone is less invasive; local tumor control seems to be as high as after surgery plus whole brain irradiation (WBRT) and distant tumor control is significantly less frequently achieved (after radiosurgery alone).
Whole brain radiation therapy (WBRT) alone versus WBRT and radiosurgery for the treatment of brain metastases.
A meta-analysis of two trials with a total of 358 participants, found no statistically significant difference in overall survival between WBRT plus radiosurgery and W BRT alone groups and a statistically significant improvement in performance status scores and decrease in steroid use was seen in the WbrT plus SRS group.
A randomized trial of surgery in the treatment of single metastases to the brain.
It is concluded that patients with cancer and a single metastasis to the brain who receive treatment with surgical resection plus radiotherapy live longer, have fewer recurrences of cancer in the brain, and have a better quality of life than similar patients treated with radiotherapy alone.
Stereotactic radiosurgery plus whole-brain radiation therapy vs stereotactic radiosurgery alone for treatment of brain metastases: a randomized controlled trial.
Compared with SRS alone, the use of W BRT plus SRS did not improve survival for patients with 1 to 4 brain metastases, but intracranial relapse occurred considerably more frequently in those who did not receive WBRT.
Whole brain irradiation following surgery or radiosurgery for solitary brain metastases: mature results of a prematurely closed randomized Trans-Tasman Radiation Oncology Group trial (TROG 98.05).
  • D. Roos, A. Wirth, B. McClure
  • Medicine
    Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology
  • 2006