A Systematic Review of Medical Treatments for Children With Autism Spectrum Disorders

@article{McPheeters2011ASR,
  title={A Systematic Review of Medical Treatments for Children With Autism Spectrum Disorders},
  author={Melissa McPheeters and Zachary Warren and Nila A. Sathe and Jennifer L. Bruzek and Shanthi Krishnaswami and Rebecca N. Jerome and Jeremy Veenstra-VanderWeele},
  journal={Pediatrics},
  year={2011},
  volume={127},
  pages={e1312 - e1321}
}
CONTEXT: As many as 1 in every 110 children in the United States has an autism spectrum disorder (ASD). Many medical treatments for ASDs have been proposed and studied, but there is currently no consensus regarding which interventions are most effective. OBJECTIVE: To systematically review evidence regarding medical treatments for children aged 12 years and younger with ASDs. METHODS: We searched the Medline, PsycInfo, and ERIC (Education Resources Information Center) databases from 2000 to May… 

Figures and Tables from this paper

Medications for Adolescents and Young Adults With Autism Spectrum Disorders: A Systematic Review
TLDR
There is a marked lack of data on use of medication treatments for adolescents and young adults with ASD, and the evidence on the use of risperidone in this age range is insufficient when considered alone but is consistent with the data in the population of children with ASD.
Review: little evidence of clear benefit for most medical treatments for children with autism spectrum disorders
  • D. Coury
  • Medicine
    Evidence Based Mental Health
  • 2011
TLDR
The authors review some of the more commonly prescribed medical treatments such as serotonin-reuptake inhibitors and present the minimal support for their use and suggest that their use be limited to those patients with greatest impairment or risk of injury.
Evidence Base Update for Autism Spectrum Disorder
  • Tristram H. SmithS. Iadarola
  • Psychology
    Journal of clinical child and adolescent psychology : the official journal for the Society of Clinical Child and Adolescent Psychology, American Psychological Association, Division 53
  • 2015
TLDR
The evidence base for ASD interventions has grown substantially since 2008; an increasing number of interventions have some empirical support; others are emerging as potentially efficacious.
Identification, Evaluation, and Management of Children With Autism Spectrum Disorder
TLDR
This single clinical report updates the 2007 American Academy of Pediatrics clinical reports on the evaluation and treatment of ASD in one publication with an online table of contents and section view available to help the reader identify topic areas within the report.
Medication in autism
TLDR
The role of medication in children and adolescents with autism spectrum disorders (ASDs) is discussed and the key symptoms that can be targeted with medication-based treatments are highlighted.
Aripiprazole for treating irritability in children & adolescents with autism: a systematic review
TLDR
Current evidence suggests that aripiprazole is as effective and safe as risperidone for treating irritability in autism, however, further studies with larger sample size and longer duration are required.
Autism Spectrum Disorder
TLDR
The goals of this chapter are to elucidate the physician’s role in the management of children and adults with ASD, especially the recognition that co-occurring medical and psychiatric conditions must be effectively diagnosed and treated.
A Survey of Parents with Children on the Autism Spectrum: Experience with Services and Treatments.
TLDR
Methods to create an autism research resource across multiple large health delivery systems are presented and services and treatments used by children with ASD and their families are described.
An Overview of Autism Spectrum Disorder, Heterogeneity and Treatment Options
TLDR
This review provides a broad overview of the history, prevalence, etiology, clinical presentation, and heterogeneity of ASD and explores the potential of a new wave of research examining objective biomarkers to facilitate the evaluation of sub-typing, diagnosis, and treatment response in ASD.
Antipsychotics Medication Use and its Metabolic Challenges for Autism Spectrum Disorders
TLDR
The purpose of this article is to review briefly the use of psychotropic medications, focusing on antipsychotics, and discuss the metabolic risks and risk factors associated with their use within children with autism.
...
...

References

SHOWING 1-10 OF 72 REFERENCES
A Systematic Review of Secretin for Children With Autism Spectrum Disorders
TLDR
Evidence from 7 randomized controlled trials supports a lack of effectiveness of secretin for the treatment of ASD symptoms including language and communication impairment, symptom severity, and cognitive and social skill deficits.
Lack of efficacy of citalopram in children with autism spectrum disorders and high levels of repetitive behavior: citalopram ineffective in children with autism.
TLDR
Results of this trial do not support the use of citalopram for the treatment of repetitive behavior in children and adolescents with autism spectrum disorders.
Treatment outcome and outcome associations in children with pervasive developmental disorders treated with selective serotonin reuptake inhibitors: a chart review.
TLDR
SSRI treatment led to modest response rate in this group of youths with PDDs and potential outcome associations include a family history of PDDs.
Risperidone in children with autism and serious behavioral problems.
TLDR
Risperidone was effective and well tolerated for the treatment of tantrums, aggression, or self-injurious behavior in children with autistic disorder and the benefit was maintained at six months.
Risperidone in children with autism and serious behavioral problems.
  • P. Accardo
  • Psychology, Medicine
    The Journal of pediatrics
  • 2003
TLDR
Risperidone was effective and well tolerated for the treatment of tantrums, aggression, or self-injurious behavior in children with autistic disorder and the benefit was maintained at six months.
A retrospective study of memantine in children and adolescents with pervasive developmental disorders
TLDR
In this open-label retrospective study, memantine was effective in a number of patients with PDDs and improvement was primarily seen clinically in social withdrawal and inattention.
Stimulant Medication Treatment of Target Behaviors in Children with Autism: A Population-Based Study
TLDR
The results indicate that psychostimulants are commonly prescribed for children with autism, and suggest that these medications may improve the target symptoms of hyperactivity, impulsivity, disinhibition and inattention.
A 3-year naturalistic study of 53 preschool children with pervasive developmental disorders treated with risperidone.
TLDR
It is suggested that low-dose risperidone may positively affect the clinical outcome in young children with PDD not only in the short-term, but also in the long-term period.
The Autism Diagnostic Observation Schedule—Generic: A Standard Measure of Social and Communication Deficits Associated with the Spectrum of Autism
TLDR
Algorithm sensitivities and specificities for autism and PD DNOS relative to nonspectrum disorders were excellent, with moderate differentiation of autism from PDDNOS.
Risperidone in Children With Autism: Randomized, Placebo-Controlled, Double-Blind Study
TLDR
Risperidone improved global functioning and social responsiveness while reducing hyperactivity and aggression in children with autism and was well tolerated.
...
...