A Systematic Review and Meta‐Analysis Evaluating the Efficacy of a Gluten‐Free Diet and a Low FODMAPS Diet in Treating Symptoms of Irritable Bowel Syndrome

  title={A Systematic Review and Meta‐Analysis Evaluating the Efficacy of a Gluten‐Free Diet and a Low FODMAPS Diet in Treating Symptoms of Irritable Bowel Syndrome},
  author={Joanna C. Dionne and Alexander Charles Ford and Yuhong Yuan and William D. Chey and Brian E. Lacy and Yuri A Saito and Eamonn M M Quigley and Paul Moayyedi},
  journal={American Journal of Gastroenterology},
OBJECTIVE: Dietary triggers such as gluten and highly fermentable oligo‐, di‐ and monosaccharides and polyols (FODMAP)‐containing foods have been associated with worsening irritable bowel syndrome (IBS) symptoms. [] Key Method Two independent reviewers screened citations and a third reviewer resolved disagreement. Two independent reviewers performed eligibility assessment and data abstraction.

A Low-FODMAP Diet Improves the Global Symptoms and Bowel Habits of Adult IBS Patients: A Systematic Review and Meta-Analysis

An LFD is effective in reducing the global symptoms and improving the bowel habits of adult IBS patients and the efficacy for IBS-D patients can also be more pronounced.

Efficacy of a low FODMAP diet in irritable bowel syndrome: systematic review and network meta-analysis

In a network analysis, a low FODMAP diet ranked first for abdominal pain severity, abdominal bloating or distension severity and bowel habit, although for the latter it was not superior to any other intervention.

Efficacy of a low-FODMAP diet in adult irritable bowel syndrome: a systematic review and meta-analysis

An updated overview of observational and intervention studies investigating the effect of a low-FODMAP diet on gastrointestinal symptoms, quality of life, nutritional adequacy, and gut microbiome in irritable bowel syndrome patients is provided.

Low FODMAP Diet and Probiotics in Irritable Bowel Syndrome: A Systematic Review With Network Meta-analysis

Lactobacillus was the most effective component for the relief of IBS symptoms; Bifidobacterium and Bacillus were possibly effective and need further verification.

Evidence-based and mechanistic insights into exclusion diets for IBS

The advantages and disadvantages of each choice of control group are outlined, the importance of collecting mechanistic data as well as symptom data in RCTs of exclusion diets in IBS are emphasized, and different approaches to how exclusion diets can be evaluated in randomized controlled trials are discussed.

The role of diet in irritable bowel syndrome: implications for dietary advice

All of these dietary therapies are viable options for individuals with IBS, with the dietitian and patient engagement at the forefront of achieving success, however, future pragmatic studies are needed to clarify the comparative efficacy and convenience of implementing these various diets into routine life.

Dietary interventions and irritable bowel syndrome – what really works?

Food is both trigger of IBS symptoms and therapeutic tool, and FODMAPs that are well tolerated should be reintroduced in daily diet to increase acceptability of the diet, and limit potentially harmful effects.

Gluten-free Diet Reduces the Risk of Irritable Bowel Syndrome: A Mendelian Randomization Analysis

Taking a diet of lower gluten intake into account in IBS prevention and clinical practice is suggested, suggesting GFD might be a protective factor of IBS.

The low-FODMAP diet as an effective tool for managing irritable bowel syndrome - an assessment of adult patients' knowledge of dietary guidelines.

The surveyed population was characterized by high levels of knowledge about the low-FODMAP diet, but many respondents did not strictly comply with dietary guidelines, in particular the duration of each dietary phase.



The Effect of Dietary Intervention on Irritable Bowel Syndrome: A Systematic Review

More evidence is needed before generally recommending elimination diets for IBS patients, as the evidence for the efficacy of dietary therapies has not been evaluated systematically.

A Diet Low in FODMAPs Reduces Symptoms in Patients With Irritable Bowel Syndrome and A Probiotic Restores Bifidobacterium Species: A Randomized Controlled Trial.

In a placebo-controlled study of patients with IBS, a low FODMAP diet associates with adequate symptom relief and significantly reduced symptom scores compared with placebo.

A Randomized Controlled Trial Comparing the Low FODMAP Diet vs. Modified NICE Guidelines in US Adults with IBS-D

In this US trial, 40–50% of patients reported adequate relief of their IBS-D symptoms with the low FODMAP diet or a diet based on modified NICE guidelines, which led to significantly greater improvement in individual IBS symptoms, particularly pain and bloating, compared with the mNICE diet.

Diet low in FODMAPs reduces symptoms of irritable bowel syndrome as well as traditional dietary advice: a randomized controlled trial.

A diet low in FODMAPs reduces IBS symptoms as well as traditional IBS dietary advice, and combining elements from these 2 strategies might further reduce symptoms of IBS.

Non-Celiac Gluten Sensitivity Has Narrowed the Spectrum of Irritable Bowel Syndrome: A Double-Blind Randomized Placebo-Controlled Trial

Using the term of IBS can therefore be misleading and may deviate and postpone the application of an effective and well-targeted treatment strategy in gluten sensitive patients.

Gluten Causes Gastrointestinal Symptoms in Subjects Without Celiac Disease: A Double-Blind Randomized Placebo-Controlled Trial

“Non-celiac gluten intolerance” may exist, but no clues to the mechanism were elucidated and there were no differences in any end point in individuals with or without DQ2/DQ8.

Food elimination based on IgG antibodies in irritable bowel syndrome: a randomised controlled trial

Food elimination based on IgG antibodies may be effective in reducing IBS symptoms and is worthy of further biomedical research.

A diet low in FODMAPs reduces symptoms of irritable bowel syndrome.

In a controlled, cross-over study of patients with IBS, a diet low in FODMAPs effectively reduced functional gastrointestinal symptoms and high-quality evidence supports its use as a first-line therapy.

Systematic review: quality of trials on the symptomatic effects of the low FODMAP diet for irritable bowel syndrome

The low Fermentable Oligo‐, Di‐ Monosaccharides, and Polyoles (FODMAP) diet is a new treatment option for irritable bowel syndrome (IBS). Experts refer to the diet as supported by high level of

FODMAPs alter symptoms and the metabolome of patients with IBS: a randomised controlled trial

IBS symptoms are linked to FODMAP content and associated with alterations in the metabolome, and in subsets of patients, FOD MAPs modulate histamine levels and the microbiota, both of which could alter symptoms.