A Systematic Comparison of Traditional and Multigene Panel Testing for Hereditary Breast and Ovarian Cancer Genes in More Than 1000 Patients.

@article{Lincoln2015ASC,
  title={A Systematic Comparison of Traditional and Multigene Panel Testing for Hereditary Breast and Ovarian Cancer Genes in More Than 1000 Patients.},
  author={Stephen E. Lincoln and Yuya Kobayashi and Michael G. Anderson and Shan Yang and Andrea J Desmond and Meredith A. Mills and Geoffrey B. Nilsen and Kevin B. Jacobs and Federico A. Monzon and Allison W. Kurian and James M. Ford and Leif William Ellisen},
  journal={The Journal of molecular diagnostics : JMD},
  year={2015},
  volume={17 5},
  pages={533-44}
}
Gene panels for hereditary breast and ovarian cancer risk assessment are gaining acceptance, even though the clinical utility of these panels is not yet fully defined. Technical questions remain, however, about the performance and clinical interpretation of gene panels in comparison with traditional tests. We tested 1105 individuals using a 29-gene next-generation sequencing panel and observed 100% analytical concordance with traditional and reference data on >750 comparable variants. These 750… CONTINUE READING