A Systematic Assessment of Cardiovascular Outcomes in the Saxagliptin Drug Development Program for Type 2 Diabetes
@article{Frederich2010ASA, title={A Systematic Assessment of Cardiovascular Outcomes in the Saxagliptin Drug Development Program for Type 2 Diabetes}, author={Robert C. Frederich and John H. Alexander and Fred T. Fiedorek and Mark Donovan and Niklas Berglind and Susan Harris and Roland S. Chen and R. Wolf and Kenneth W. Mahaffey}, journal={Postgraduate Medicine}, year={2010}, volume={122}, pages={16 - 27} }
Abstract Objective: The objective was to assess the relative risk (RR) for cardiovascular (CV) events across all 8 randomized phase 2/3 trials evaluating saxagliptin in patients with type 2 diabetes mellitus. Methods: Cardiovascular events (death, myocardial infarction [MI], stroke, revascularization procedures, and cardiac ischemia) were reported by investigators through standard adverse event reporting procedures and were systematically identified. Post hoc blinded adjudication of all deaths…
224 Citations
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These results from a large Phase 3 programme support the hypothesis that linagliptin may have CV benefits in patients with T2DM.
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Al saxagliptin should be avoided in patients with heart failure or a reduced estimated glomerular filtration rate, and other dipeptidyl peptidase 4 (DPP-4) inhibitors are available which have not been associated with an increased risk of hospitalisation for heart failure.
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