A System of Two Polymerases – A Model for the Origin of Life

@article{Kunin2004ASO,
  title={A System of Two Polymerases – A Model for the Origin of Life},
  author={V. Kunin},
  journal={Origins of life and evolution of the biosphere},
  year={2004},
  volume={30},
  pages={459-466}
}
  • V. Kunin
  • Published 2004
  • Biology, Medicine
  • Origins of life and evolution of the biosphere
What was the first living molecule – RNA or protein?This question embodies the major disagreement instudies on the origin of life. The fact that incontemporary cells RNA polymerase is a protein andpeptidyl transferase consists of RNA suggests theexistence of a mutual catalytic dependence betweenthese two kinds of biopolymers. I suggest that thisdependence is a `frozen accident', a remnant from thefirst living system. This system is proposed to be acombination of an RNA molecule capable of… Expand
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References

SHOWING 1-10 OF 28 REFERENCES
On the early evolution of RNA polymerase
TLDR
The phylogenetic importance of the eubacterial β′ subunit from RNA polymerase and its homologues is emphasized, because it allows the study of the evolutionary relationships of the major cellular lines (eubacteria, archaebacteria, and eukaryotes) as well as of some viral lineages. Expand
The RNA-world and co-evolution hypotheses and the origin of life: Implications, research strategies and perspectives
  • N. Lahav
  • Biology, Medicine
  • Origins of life and evolution of the biosphere
  • 2005
TLDR
A central element in the proposed experimental strategies is the study of the catalytic activities of very small peptides and RNA-like oligomers, according to existing, as well as to yet-to-be-invented scenarios of the two hypotheses under consideration. Expand
Peptide bond formation by in vitro selected ribozymes
TLDR
This work demonstrates the in vitro selection of ribozymes (196 nucleotides) that perform the same peptidyl transferase reaction as the ribosome: that is, they can join amino acids by a peptide bond. Expand
Structurally complex and highly active RNA ligases derived from random RNA sequences.
TLDR
Seven families of RNA ligases, previously isolated from random RNA sequences, fall into three classes on the basis of secondary structure and regiospecificity of ligation, which implies the existence of a large number of distinct RNA structures of equivalent complexity and activity. Expand
RNA-catalysed RNA polymerization using nucleoside triphosphates
TLDR
An RNA is described that synthesizes RNA using the same reaction as that employed by protein enzymes that catalyse RNA polymerization, and shows marked template fidelity. Expand
A self-replicating peptide
TLDR
It is shown that a 32-residue α-helical peptide based on the leucine-zipper domain of the yeast transcription factor GCN4 can act autocatalytically in templating its own synthesis by accelerating the thioester-promoted amide-bond condensation of 15- and 17-residine fragments in neutral, dilute aqueous solutions. Expand
EMERGENCE OF TEMPLATE-AND-SEQUENCE-DIRECTED (TSD) SYNTHESES: I. A BIO-GEOCHEMICAL MODEL
  • N. Lahav, S. Nir
  • Chemistry, Medicine
  • Origins of life and evolution of the biosphere
  • 2004
TLDR
A biogeochemical model for the evolution of template-and-sequence-directed (TSD) syntheses of biological templates (proto-RNAs) and catalysts (peptides) is described and is the basis for a computer program. Expand
Overlapping nucleotide determinants for specific aminoacylation of RNA microhelices.
TLDR
A seven-base pair microhelix that recapitulates a glycine transfer RNA (tRNA) acceptor helix can be specifically aminoacylated with glycine, showing that the specific acceptor stem nucleotide bases confer aminoacylation. Expand
Variant minihelix RNAs reveal sequence‐specific recognition of the helical tRNA(Ser) acceptor stem by E.coli seryl‐tRNA synthetase.
Aminoacylation rate determinations for a series of variant RNA minihelix substrates revealed that Escherichia coli seryl‐tRNA synthetase (SerRS) recognizes the 1–72 through 5–68 base pairs of theExpand
RNA evolution and the origins of life
TLDR
It is doubtful that life began with RNA, but consideration of what came before RNA must take into account relevant information from geochemistry, prebiotic chemistry and nucleic acid biochemistry. Expand
...
1
2
3
...