A Synthetic Optogenetic Transcription Device Enhances Blood-Glucose Homeostasis in Mice

@article{Ye2011ASO,
  title={A Synthetic Optogenetic Transcription Device Enhances Blood-Glucose Homeostasis in Mice},
  author={Haifeng Ye and Marie Daoud-El Baba and Ren-Wang Peng and Martin Fussenegger},
  journal={Science},
  year={2011},
  volume={332},
  pages={1565 - 1568}
}
An implanted device using blue-light–triggered expression of the glucagon-like peptide 1 attenuates diabetes in mice. Synthetic biology has advanced the design of genetic devices that can be used to reprogram metabolic activities in mammalian cells. By functionally linking the signal transduction of melanopsin to the control circuit of the nuclear factor of activated T cells, we have designed a synthetic signaling cascade enabling light-inducible transgene expression in different cell lines… 

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