A Synthetic Hybrid Molecule for the Selective Removal of Human Pluripotent Stem Cells from Cell Mixtures.

  title={A Synthetic Hybrid Molecule for the Selective Removal of Human Pluripotent Stem Cells from Cell Mixtures.},
  author={Di Mao and Shin Ando and Shin-ichi Sato and Ying Qin and Naonori Hirata and Yousuke Katsuda and Eihachiro Kawase and Ting-Fang Kuo and Itsunari Minami and Yuji Shiba and Kazumitsu Ueda and Norio Nakatsuji and Motonari Uesugi},
  journal={Angewandte Chemie},
  volume={56 7},
A major hurdle in stem cell therapy is the tumorigenic risk of residual undifferentiated stem cells. This report describes the design and evaluation of synthetic hybrid molecules that efficiently reduce the number of human induced pluripotent stem cells (hiPSCs) in cell mixtures. The design takes advantage of Kyoto probe 1 (KP-1), a fluorescent chemical probe for hiPSCs, and clinically used anticancer drugs. Among the KP-1-drug conjugates we synthesized, we found an exceptionally selective… 
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