A Syndrome produced by Diverse Nocuous Agents

  title={A Syndrome produced by Diverse Nocuous Agents},
  author={Hans Selye},
  • H. Selye
  • Published 1 July 1936
  • Medicine
  • Nature
EXPERIMENTS on rats show that if the organism is severely damaged by acute non-specific nocuous agents such as exposure to cold, surgical injury, production of spinal shock (transcision of the cord), excessive muscular exercise, or intoxications with sublethal doses of diverse drugs (adrenaline, atropine, morphine, formaldehyde, etc.), a typical syndrome appears, the symptoms of which are independent of the nature of the damaging agent or the pharmacological type of the drug employed, and… Expand
Why a Small Worm Is Not Crazy
Scientifically and scientifically, Selye (1936) discovered that if the organism is severely damaged by acute non-specific nocuous agents such as exposure to cold, surgical injury, production of spinal shock, excessive muscular exercise, or intoxications with sublethal doses of diverse drugs, a typical syndrome appears. Expand
General Adaptation Syndrome
The General Adaptation Syndrome is a cluster of bodily responses to severe, prolonged stressors that was first described by Hans Selye and seen in animals exposed to extreme cold and heat, intense sound or light, forced exercise, injections of various organ extracts or formalin, and other potent biological challenges to homeostasis. Expand
Biological origins of protective mechanisms activated by the disruption of higher nervous activity
  • A. Inozemtsev
  • Biology
  • Moscow University Biological Sciences Bulletin
  • 2009
Unexpected changes in experimental conditions are shown to cause similar responses and effects of nootropic drugs in higher and lower vertebrates and higher invertebrates. The basis of this universalExpand
Opioid-sensitive peripheral neuronal activity in the modulation of gastric mucosal injury.
There is growing evidence that capsaicin-sensitive afferent neurones participate in the protective mechanisms of the gastric mucosa against damage. Animals pretreated systemically with capsaicin, atExpand
Cell signaling and fate through the redox lens
A snapshot of the interplay between cellular redox milieu and diverse signaling networks and metabolic pathways is presented and the long-held dogmatic view of redox stress as an insult, invariably associated with cellular/tissue injury, damage and death, has not only been challenged but also dispelled. Expand
Role of Brain Peptides in the Ulcerogenic Response to Stress
It was Selye in 1936 who was the first to provide experimental evidence that the acute formation of ulcers in the digestive tract represented a characteristic manifestation of exposure to various “nocuous stimuli”. Expand
2 Pathophysiology of Acute Pain
In addition to the ethical and humanitarian reasons for minimizing pain and suffering is the recognition that both physiologic and pathophysiologic responses to poorly controlled pain may haveExpand
Experimental Model for Production of Perforating Duodenal Ulcers by Cysteamine in the Rat
IT has long been known that exposure to stress, in itself1 or in combination with various sensitizing agents, particularly glucocorticoids2,3, can produce acute haemorrhagic erosions of the gastricExpand
On the mechanism through which hydrocortisone affects the resistance of tissues to injury; an experimental study with the granuloma pouch technique.
  • H. Selye
  • Medicine
  • Journal of the American Medical Association
  • 1953
The purpose of this communication is to report on recent experiments that suggest an alternative interpretation that is compatible with the fact that these hormones can both protect and sensitize to various nonspecifically injurious agents (noxae). Expand
The stress response in subarachnoid haemorrhage and head injury.
It became apparent to Selye and, subsequently in 1966 to Raab in particular, that under certain circumstances increased endogenous production during stress or exogenous administration of ACTH, corticosteroids and catecholamines can become the cause of disease, that is, hypertension, diabetes, myocarditis etc. Expand


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This recent book of Prof. Cannon is the fourth of a series of volumes giving the conclusions of the researches he and his colleagues have been carrying out over a period of more than thirty years, treating the relation of the autonomic system to the balance of physiological processes. Expand