A Survey of Genomic Traces Reveals a Common Sequencing Error, RNA Editing, and DNA Editing

@inproceedings{Zaranek2010ASO,
  title={A Survey of Genomic Traces Reveals a Common Sequencing Error, RNA Editing, and DNA Editing},
  author={Alexander Wait Zaranek and Erez Y. Levanon and Tomer Zecharia and Tom Clegg and George M. Church},
  booktitle={PLoS genetics},
  year={2010}
}
While it is widely held that an organism's genomic information should remain constant, several protein families are known to modify it. Members of the AID/APOBEC protein family can deaminate DNA. Similarly, members of the ADAR family can deaminate RNA. Characterizing the scope of these events is challenging. Here we use large genomic data sets, such as the two billion sequences in the NCBI Trace Archive, to look for clusters of mismatches of the same type, which are a hallmark of editing events… CONTINUE READING
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