A Surveillance Method for the Early Identification of Idiosyncratic Adverse Drug Reactions

  title={A Surveillance Method for the Early Identification of Idiosyncratic Adverse Drug Reactions},
  author={Fatma Etwel and Michael J Rieder and John Richard Bend and Gideon Koren},
  journal={Drug Safety},
AbstractBackground: Pemoline is a CNS stimulant that was introduced in 1975 in the US and was used to treat children with attention deficit hyperactivity disorder. Pemoline was withdrawn from the market 30 years later because of fatal hepatotoxicity associated with its use. Objective: To create a system that will estimate the potential association between a serious adverse event and a medication early in its marketing cycle. Method: All case reports of acute liver failure associated with… 

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