A Subtype-Specific Function for the Extracellular Domain of Neuroligin 1 in Hippocampal LTP

@article{Shipman2012ASF,
  title={A Subtype-Specific Function for the Extracellular Domain of Neuroligin 1 in Hippocampal LTP},
  author={Seth L. Shipman and Roger A Nicoll},
  journal={Neuron},
  year={2012},
  volume={76},
  pages={309-316}
}
At neuronal excitatory synapses, two major subtypes of the synaptic adhesion molecule neuroligin are present. These subtypes, neuroligin 1 and neuroligin 3, have roles in synaptogenesis and synaptic maintenance that appear largely overlapping. In this study, we combine electrophysiology with molecular deletion and replacement of these proteins to identify similarities and differences between these subtypes. In doing so, we identify a subtype-specific role in LTP for neuroligin 1 in young CA1… CONTINUE READING
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