A Subset of Chondrogenic Cells Provides Early Mesenchymal Progenitors in Growing Bones

@inproceedings{Ono2014ASO,
  title={A Subset of Chondrogenic Cells Provides Early Mesenchymal Progenitors in Growing Bones},
  author={N Ono and Wanida Ono and Takashi Nagasawa and Henry M. Kronenberg},
  booktitle={Nature Cell Biology},
  year={2014}
}
The hallmark of endochondral bone development is the presence of cartilaginous templates, in which osteoblasts and stromal cells are generated to form mineralized matrix and support bone marrow haematopoiesis. However, the ultimate source of these mesenchymal cells and the relationship between bone progenitors in fetal life and those in later life are unknown. Fate-mapping studies revealed that cells expressing cre-recombinases driven by the collagen II (Col2) promoter/enhancer and their… CONTINUE READING
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