A Study of Early Pregnancy Factor Activity in Preimplantation

@article{XiaoGuang1997ASO,
  title={A Study of Early Pregnancy Factor Activity in Preimplantation},
  author={Fan Xiao‐Guang and Zheng Zhen‐Qun and Fan Xiao‐Guang and Zheng Zhen‐Qun},
  journal={American Journal of Reproductive Immunology},
  year={1997},
  volume={37}
}
PROBLEM and METHOD: Early pregnancy factor (EPF), an Immunosuppressive substance, which appears in pregnant women's sera 48 h after fertilization, is a kind of pregnancy‐specific protein. To determine whether the EPF activity could be a super early indicator of pregnancy, we used rosette inhibition assay to detect EPF activity in the sera, collected from 70 women 2–7 days after ovulation intending to conceive monitored by ultrasonography. Simultaneously we selected 40 non‐pregnant sera and 12… 
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References

SHOWING 1-10 OF 26 REFERENCES

Fertilization and early pregnancy loss in healthy women attempting conception.

The rosette inhibition test was used to monitor the activity of an early pregnancy factor (EPF) in sera collected from 18 healthy women who were attempting to conceive, indicating a 67% rate of fertilization and a 36% rates of early conceptus losses.

Detection of fetal wastage.

  • B. Rolfe
  • Medicine
    Fertility and sterility
  • 1982

A Study of Early Pregnancy Factor Activity in the Sera of Patients With Unexplained Spontaneous Abortion

Sera samples obtained from 51 patients with unexplained spontaneous abortions including 20 threatened abortions, 13 inevitable abortions, and 18 intrauterine fetal growth retardation, as well as 9 sera from 9 patients with hydatidiform mole, were detected for early pregnancy factor (EPF) by rosette inhibition assay.

Detection of early pregnancy factor-like activity in human amniotic fluid.

The immunological significance of the EPF-like substance in amniotic fluid may be important to the survival of semiallogeneic conceptus, and its activity significantly correlated with that of EPF in serum from the same donor is recognized.

Detection of early pregnancy factor in human sera.

The results showed that an immunosuppressive substance, named early pregnancy factor (EPF), did exist in the pregnancy sera and confirmed that the EPF activity was very high in the early pregnant stage, gradually decreased with the continuance of gestation, and disappeared at 8 weeks before delivery when the mean RIT for sera had fallen in the RIT nonpregnant range.

Detection of early pregnancy factor in human sera.

  • Z. QinZ. Zheng
  • Medicine
    American journal of reproductive immunology and microbiology : AJRIM
  • 1987
The rosette inhibition titers for sera from 94 women at various stages of gestation showed that an immunosuppressive substance, named early pregnancy factor (EPF), did exist in the pregnancy sera and confirmed that the EPF activity was very high in the early pregnant stage and gradually decreased with the continuance of gestation.

Detection of Early Pregnancy Factor in Fetal Sera

The results revealed the presence of EPF in fetal serum during gestation and its possible role of immunological regulation on survival of semiallogeneic conceptus have thus been discussed.

Detection of early pregnancy factor in fetal sera.

The results revealed the presence of EPF in fetal serum during gestation and its possible role of immunological regulation on survival of semiallogeneic conceptus have thus been discussed.

The appearance and characteristics of early pregnancy factor in the pig.

The occurrence of early pregnancy factor in the pig has been established by the rosette inhibition test and by the criteria that gel filtration of serum resulted in a number of peaks of activity

A test for early pregnancy in sheep.