A Study of Alveolar Rhabdomyosarcoma Copy Number Alterations by Single Nucleotide Polymorphism Analysis.

@article{Lynn2014ASO,
  title={A Study of Alveolar Rhabdomyosarcoma Copy Number Alterations by Single Nucleotide Polymorphism Analysis.},
  author={Miriam Anne Lynn and Naisha Shah and Judith A. Conroy and Sean Ennis and Thomas Colin Morris and David Richard Betts and M. J. O'sullivan},
  journal={Diagnostic molecular pathology : the American journal of surgical pathology, part B},
  year={2014}
}
Rhabdomyosarcoma, the most common pediatric soft tissue malignancy arises in 2 major histologic forms: embryonal and alveolar. Classically, the alveolar subtype is characterized by a chromosomal translocation t(2;13)(q35;q14) or t(1;13)(p36;q14) fusing the PAX3 or PAX7 gene, respectively, to the FOXO1 gene, although fusion-negative cases of alveolar rhabdomyosarcoma (ARMS) occur; these share considerably more with the genomic profiles and biological behavior of embryonal rhabdomyosarcoma than… CONTINUE READING

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