A Structurally and Functionally Biomimetic Biphasic Scaffold for Intervertebral Disc Tissue Engineering

@inproceedings{Choy2015ASA,
  title={A Structurally and Functionally Biomimetic Biphasic Scaffold for Intervertebral Disc Tissue Engineering},
  author={Andrew Tsz Hang Choy and Barbara P Chan and Lachlan J. Smith},
  booktitle={PloS one},
  year={2015}
}
Tissue engineering offers high hopes for the treatment of intervertebral disc (IVD) degeneration. Whereas scaffolds of the disc nucleus and annulus have been extensively studied, a truly biomimetic and mechanically functional biphasic scaffold using naturally occurring extracellular matrix is yet to be developed. Here, a biphasic scaffold was fabricated with collagen and glycosaminoglycans (GAGs), two of the most abundant extracellular matrix components in the IVD. Following fabrication, the… CONTINUE READING
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