A Structural Model of the Pore-Forming Region of the Skeletal Muscle Ryanodine Receptor (RyR1)

@article{Ramachandran2009ASM,
  title={A Structural Model of the Pore-Forming Region of the Skeletal Muscle Ryanodine Receptor (RyR1)},
  author={Srinivas Ramachandran and Adrian W. R. Serohijos and Le Xu and Gerhard Meissner and Nikolay V. Dokholyan},
  journal={PLoS Computational Biology},
  year={2009},
  volume={5},
  pages={893 - 922}
}
Ryanodine receptors (RyRs) are ion channels that regulate muscle contraction by releasing calcium ions from intracellular stores into the cytoplasm. Mutations in skeletal muscle RyR (RyR1) give rise to congenital diseases such as central core disease. The absence of high-resolution structures of RyR1 has limited our understanding of channel function and disease mechanisms at the molecular level. Here, we report a structural model of the pore-forming region of RyR1. Molecular dynamics… CONTINUE READING
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