A Strongly Interacting Pair of Residues on the Contact Surface of Charybdotoxin and a Shaker K+ Channel

@article{Naranjo1996ASI,
  title={A Strongly Interacting Pair of Residues on the Contact Surface of Charybdotoxin and a Shaker K+ Channel},
  author={D. Naranjo and C. Miller},
  journal={Neuron},
  year={1996},
  volume={16},
  pages={123-130}
}
  • D. Naranjo, C. Miller
  • Published 1996
  • Chemistry, Medicine
  • Neuron
  • Charybdotoxin, a peptide neurotoxin of known molecular structure, blocks Shaker K+ channels by binding to a receptor at the outer opening of the ion conduction pathway. Analysis of variants of CTX at position 29 and of Shaker at position 449 shows that these two residues interact closely in the channel-toxin complex. The CTX mutation M29I leads to a slight strengthening of block when tested on Shaker-449T; the same CTX mutation weakens block 1700-fold when tested on Shaker-449F. The known… CONTINUE READING
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