A Strategy for the Convergent and Stereoselective Assembly of Polycyclic Molecules.

@article{Robinson2018ASF,
  title={A Strategy for the Convergent and Stereoselective Assembly of Polycyclic Molecules.},
  author={E. E. Robinson and R. J. Thomson},
  journal={Journal of the American Chemical Society},
  year={2018},
  volume={140 5},
  pages={
          1956-1965
        }
}
The stereoselective oxidative coupling of cyclic ketones via silyl bis-enol ethers followed by ring-closing metathesis is shown to be a general and powerful reaction sequence for the preparation of diverse polycyclic scaffolds from simple precursors. The modular strategy successfully constructs substructures prevalent in numerous bioactive natural product families, varying in substitution and carbocyclic composition. Several of the prepared compounds were shown to possess potent cytotoxic… Expand
Rh(I)/Sc(OTf)3-co-catalyzed Michael addition of ammonium ylide to (E)-1,4-enediones: synthesis of functionalized 1,4-diketones
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