A Stochastic Markov Chain Model to Describe Lung Cancer Growth and Metastasis

  title={A Stochastic Markov Chain Model to Describe Lung Cancer Growth and Metastasis},
  author={Paul K. Newton and J. Mason and Kelly Bethel and Lyudmila Bazhenova and Jorge Nieva and Peter A Kuhn},
  booktitle={PloS one},
A stochastic Markov chain model for metastatic progression is developed for primary lung cancer based on a network construction of metastatic sites with dynamics modeled as an ensemble of random walkers on the network. We calculate a transition matrix, with entries (transition probabilities) interpreted as random variables, and use it to construct a circular bi-directional network of primary and metastatic locations based on postmortem tissue analysis of 3827 autopsies on untreated patients… CONTINUE READING
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