Corpus ID: 17771154

A Standardized Withania Somnifera Extract Significantly Reduces Stress-Related Parameters in Chronically Stressed Humans: A Double-Blind, Randomized, Placebo-Controlled Study

@inproceedings{Auddy2008ASW,
  title={A Standardized Withania Somnifera Extract Significantly Reduces Stress-Related Parameters in Chronically Stressed Humans: A Double-Blind, Randomized, Placebo-Controlled Study},
  author={Biswajit Auddy and Jayaram Hazra and Achintya Mitra and Bruce G. Abedon and Shibnath. Ghosal and Bidhan Nagar},
  year={2008}
}
Withania somnifera (WS) has historically been used in Asia for treating stress-related health conditions. [...] Key Method Participants were randomly assigned to WSE (125 mg QD, 125 mg BID, or 250 mg BID) or placebo groups. Stress levels were assessed at Days 0, 30, and 60 using a modified Hamilton anxiety (mHAM-A) scale. Biochemical and clinical variables were measured at Days 0 and 60. Of 130 subjects enrolled, 98 completed the study. Between Days 0 and 60, the WSE 125 mg QD group decreased significantly moreā€¦Expand
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Adjunctive Use of a Standardized Extract of Withania somnifera (Ashwagandha) to Treat Symptom Exacerbation in Schizophrenia: A Randomized, Double-Blind, Placebo-Controlled Study.
TLDR
This early study suggests that adjunctive treatment with a standardized extract of Withania somnifera provides significant benefits, with minimal side effects, for negative, general, and total symptoms and stress in patients with recent exacerbation of schizophrenia. Expand
An investigation into the stress-relieving and pharmacological actions of an ashwagandha (Withania somnifera) extract
TLDR
These findings suggest that ashwagandha's stress-relieving effects may occur via its moderating effect on the hypothalamus-pituitary-adrenal axis, and further investigation utilizing larger sample sizes, diverse clinical and cultural populations, and varying treatment dosages are needed to substantiate these findings. Expand
No benefit adding eleutherococcus senticosus to stress management training in stress-related fatigue/weakness, impaired work or concentration, a randomized controlled study.
TLDR
Almost all parameters improved significantly over time without group differences, and significant differences were found in mental fatigue and restlessness, both in favor of COM vs. ES. Expand
Body Weight Management in Adults Under Chronic Stress Through Treatment With Ashwagandha Root Extract
TLDR
It is suggested that Ashwagandha root extract can be used for body weight management in adults under chronic stress and was found to be safe and tolerable. Expand
No Benefi t Adding Eleutherococcus senticosus to Stress Management Training in Stress-Related Fatigue/ Weakness, Impaired Work or Concentration, A Randomized Controlled Study
  • 2013
ā–¼ Introduction: Plant adaptogens are traditionally used for stress-related symptoms, but clinical evidence is inconsistent. This trial explored the eff ects of 120 mg/day Eleutherococcus senticosusā€¦ Expand
EFFECT OF WITHANIA SOMNIFERA EXTRACT ON MENTAL STRESS INDUCED CHANGES IN HEMODYNAMIC PROPERTIES AND ARTERIAL WAVE REFLECTIONS IN HEALTHY SUBJECTS
Mental stress is known to contribute to the risk for hypertension and coronary atherosclerosis. Withania somnifera is well known for its anti-stress and antioxidant activity. The present study wasā€¦ Expand
No Bene fi t Adding Eleutherococcus senticosus to Stress Management Training in Stress-Related Fatigue / Weakness , Impaired Work or Concentration , A Randomized Controlled
ā–¼ Introduction: Plant adaptogens are traditionally used for stress-related symptoms, but clinical evidence is inconsistent. This trial explored the eff ects of 120 mg/day Eleutherococcus senticosusā€¦ Expand
Effect of standardized aqueous extract of Withania somnifera on tests of cognitive and psychomotor performance in healthy human participants
TLDR
It is suggested that Withania somnifera extract can improve cognitive and psychomotor performance and may, therefore, be a valuable adjunct in the treatment of diseases associated with cognitive impairment. Expand
A randomized, double blind, placebo controlled study to evaluate the effects of ashwagandha (Withania somnifera) extract on sleep quality in healthy adults.
OBJECTIVE Non-restorative sleep (NRS) affects 10% people worldwide, leading to poor sleep quality, as well as physical and cognitive fatigue. This is the first human study in which an extract ofā€¦ Expand
A Prospective, Randomized Double-Blind, Placebo-Controlled Study of Safety and Efficacy of a High-Concentration Full-Spectrum Extract of Ashwagandha Root in Reducing Stress and Anxiety in Adults
TLDR
The findings of this study suggest that a high-concentration full-spectrum Ashwagandha root extract safely and effectively improves an individual's resistance towards stress and thereby improves self-assessed quality of life. Expand
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References

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Adaptogenic activity of Withania somnifera : an experimental study using a rat model of chronic stress
Withania somnifera (WS) Dunal is classified in Ayurveda, the ancient Hindu system of medicine, as a rasayana, a group of plant-derived drugs reputed to promote physical and mental health, augmentā€¦ Expand
Withania somnifera Root Extract Prevents DMBA-Induced Squamous Cell Carcinoma of Skin in Swiss Albino Mice
TLDR
It can be inferred that WSRE possesses potential chemopreventive activity in this experimental model of cancer, and may be linked to the antioxidant/free radical-scavenging constituents of the extract. Expand
Neuroprotective effects of Withania somnifera on 6-hydroxydopamine induced Parkinsonism in rats
TLDR
The study demonstrates that the extract of W. somnifera may be helpful in protecting the neuronal injury in Parkinson's disease and reverse all the parameters significantly in a dose-dependent manner. Expand
Immunomodulatory and CNS effects of sitoindosides IX and X, two new glycowithanolides from Withania somnifera
Two new glycowithanolides, sitoindoside IX (1) and sitoindoside X (2), isolated from Withania somnifera Dun., were evaluated for their immunomodulatory and CNS effects (antiā€stress, memory andā€¦ Expand
Antioxidant activity of glycowithanolides from Withania somnifera.
TLDR
Antioxidant effect of active principles of W. somnifera may explain, at least in part, the reported antistress, immunomodulatory, cognition-facilitating, anti-inflammatory and anti-aging effects produced by them in experimental animals, and in clinical situations. Expand
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TLDR
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Treatment of osteoarthritis with a herbomineral formulation: a double-blind, placebo-controlled, cross-over study.
TLDR
The clinical efficacy of a herbomineral formulation containing roots of Withania somnifera, the stem of Boswellia serrata, rhizomes of Curcuma longa and a zinc complex, was evaluated in patients with osteoarthritis. Expand
Effects of glycowithanolides from Withania somnifera on an animal model of Alzheimer's disease and perturbed central cholinergic markers of cognition in rats
TLDR
The findings validate the medharasayan (promoter of learning and memory) effect of W. somnifera, as has been reported in Ayurveda, and reverse both IAā€induced cognitive deficit and the reduction in cholinergic markers after 2 weeks of treatment. Expand
Adrenocorticosterone alterations in male, albino mice treated with Trichopus zeylanicus, Withania somnifera and Panax ginseng preparations
The levels of corticosterone were estimated by the HPLC method in the adrenal glands of stressed (5ā€…h constant swimming) male albino mice treated with Trichopus zeylanicus, Withania somnifera andā€¦ Expand
Immunomodulatory activity of Withania somnifera.
TLDR
The results confirm the immunomodulatory activity of W. somnifera extract, which is a known immunosorbent in indigenous medicine, and Administration of Withania extract inhibited delayed type hypersentivity reaction in mice. Expand
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