A Stability-Indicating Assay of Brimonidine Tartrate Ophthalmic Solution and Stress Testing Using HILIC

@article{Ali2009ASA,
  title={A Stability-Indicating Assay of Brimonidine Tartrate Ophthalmic Solution and Stress Testing Using HILIC},
  author={Mohammed Shahid Ali and Aamer Roshanali Khatri and Muhammad Imran Munir and Mohsin Ul Haq Ghori},
  journal={Chromatographia},
  year={2009},
  volume={70},
  pages={539-544}
}
A stability-indicating hydrophilic interaction liquid chromatography (HILIC) method has been developed and validated for the quantitative determination of Brimonidine tartrate (BT) formulated as an ophthalmic solution. Isocratic separation was achieved using an acetonitrile-buffer mixture (92:8, v/v) at pH 7.1 on an unmodified silica column (250 × 4.6 mm, 5 μm). The drug was subjected to oxidative, hydrolytic, photolytic and thermal stress conditions and complete separation was achieved for the… CONTINUE READING

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