A Src homology 3-binding sequence on the C terminus of Sprouty2 is necessary for inhibition of the Ras/ERK pathway downstream of fibroblast growth factor receptor stimulation.

@article{Lao2006ASH,
  title={A Src homology 3-binding sequence on the C terminus of Sprouty2 is necessary for inhibition of the Ras/ERK pathway downstream of fibroblast growth factor receptor stimulation.},
  author={Dieu-Hung Lao and Sumana Chandramouli and Permeen Yusoff and Chee Wai Fong and Tzuen Yih Saw and Lai Peng Tai and Chye Yun Yu and Hwei Fen Leong and Graeme R. Guy},
  journal={The Journal of biological chemistry},
  year={2006},
  volume={281 40},
  pages={29993-30000}
}
Because the Sprouty (Spry) proteins were shown to be inhibitors of the mainstream Ras/ERK pathway, there has been considerable interest in ascertaining their mechanism of action especially since a possible role as tumor suppressors for these inhibitory proteins has been suggested. We compared the ability of the mammalian Spry isoforms to inhibit the Ras/ERK pathway in the context of fibroblast growth factor receptor (FGFR) signaling. Spry2 is considerably more inhibitory than Spry1 or Spry4… CONTINUE READING
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