A Spontaneous Acinar Cell Carcinoma Model for Monitoring Progression of Pancreatic Lesions and Response to Treatment Through Noninvasive Bioluminescence Imaging

@article{Zhang2009ASA,
  title={A Spontaneous Acinar Cell Carcinoma Model for Monitoring Progression of Pancreatic Lesions and Response to Treatment Through Noninvasive Bioluminescence Imaging},
  author={N. Zhang and S. Lyons and E. Lim and P. Lassota},
  journal={Clinical Cancer Research},
  year={2009},
  volume={15},
  pages={4915 - 4924}
}
  • N. Zhang, S. Lyons, +1 author P. Lassota
  • Published 2009
  • Biology, Medicine
  • Clinical Cancer Research
  • Purpose: We have generated an EL1-luc/TAg transgenic mouse model that develops spontaneous and bioluminescent acinar cell carcinomas. We applied this model to noninvasively monitor tumor development and drug response. Experimental Design: EL1-luc/TAg transgenic mice of 11 weeks of age were treated with rapamycin (5 mg/kg, i.p.) or vehicle for 6 to 12 weeks. Tumor development was monitored through bioluminescence imaging and necropsy at the study end point. Results: EL1-luc/TAg transgenic mice… CONTINUE READING
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