A Spectral Approach Integrating Functional Genomic Annotations for Coding and Noncoding Variants

@inproceedings{IonitaLaza2016ASA,
  title={A Spectral Approach Integrating Functional Genomic Annotations for Coding and Noncoding Variants},
  author={Iuliana Ionita-Laza and Kenneth Jordan McCallum and Bin Xu and Joseph D. Buxbaum},
  booktitle={Nature Genetics},
  year={2016}
}
Over the past few years, substantial effort has been put into the functional annotation of variation in human genome sequences. Such annotations can have a critical role in identifying putatively causal variants for a disease or trait among the abundant natural variation that occurs at a locus of interest. The main challenges in using these various annotations include their large numbers and their diversity. Here we develop an unsupervised approach to integrate these different annotations into… CONTINUE READING