A Specific Transitory Increase in Intracellular Calcium Induced by Progesterone Promotes Acrosomal Exocytosis in Mouse Sperm.

@article{Romarowski2016AST,
  title={A Specific Transitory Increase in Intracellular Calcium Induced by Progesterone Promotes Acrosomal Exocytosis in Mouse Sperm.},
  author={Ana Romarowski and Claudia S{\'a}nchez-C{\'a}rdenas and H{\'e}ctor V Ram{\'i}rez-G{\'o}mez and Lis del C Puga Molina and Claudia Lydia Trevi{\~n}o and Arturo Hern{\'a}ndez-Cruz and Alberto Darszon and Mariano G Buffone},
  journal={Biology of reproduction},
  year={2016},
  volume={94 3},
  pages={63}
}
During capacitation, sperm acquire the ability to undergo the acrosome reaction (AR), an essential step in fertilization. Progesterone produced by cumulus cells has been associated with various physiological processes in sperm, including stimulation of AR. An increase in intracellular Ca(2+) ([Ca(2+)]i) is necessary for AR to occur. In this study, we… CONTINUE READING