A Specific Primed Immune Response in Drosophila Is Dependent on Phagocytes

@article{Pham2007ASP,
  title={A Specific Primed Immune Response in Drosophila Is Dependent on Phagocytes},
  author={Linh Nguyen Pham and Marc S Dionne and Mimi M Shirasu-Hiza and David S Schneider},
  journal={PLoS Pathogens},
  year={2007},
  volume={3},
  pages={457 - 483}
}
Drosophila melanogaster, like other invertebrates, relies solely on its innate immune response to fight invading microbes; by definition, innate immunity lacks adaptive characteristics. However, we show here that priming Drosophila with a sublethal dose of Streptococcus pneumoniae protects against an otherwise-lethal second challenge of S. pneumoniae. This protective effect exhibits coarse specificity for S. pneumoniae and persists for the life of the fly. Although not all microbial challenges… CONTINUE READING
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