A Specific Chemical Difference Between the Globins of Normal Human and Sickle-Cell Anæmia Hæmoglobin

  title={A Specific Chemical Difference Between the Globins of Normal Human and Sickle-Cell An{\ae}mia H{\ae}moglobin},
  author={Vernon M. Ingram},
  • V. Ingram
  • Published 13 October 1956
  • Biology, Medicine
  • Nature
A Specific Chemical Difference Between the Globins of Normal Human and Sickle-Cell Anaemia Haemoglobin 

Gene Mutations in Human Hæmoglobin: the Chemical Difference Between Normal and Sickle Cell Hæmoglobin

Gene Mutations in Human Haemoglobin: the Chemical Difference Between Normal and Sickle Cell Haemocytes is illustrated.

Abnormal human haemoglobins.

  • V. Ingram
  • Biology
    Proceedings of the Royal Society of Medicine
  • 1958


  • C. Stetson
  • Biology
    The Journal of experimental medicine
  • 1966
Electron microscopic and other evidence have provided support for the hypothesis that the sickling phenomenon is due to the intracellular formation of long slender crystals of reduced sickle

Structural Similarities between Hemoglobins A and F

A striking similarity has been found between the composition of peptides obtained from tryptic digestion of normal adult hemoglobin (hemoglobin A) and fetal hemoglobin (hemoglobin F).

Modulation of the phenotypic diversity of sickle cell anemia.

This review focuses on genetically determined modulation of hemoglobin concentration and fetal hemoglobin levels, which have important influences upon sickle hemoglobin polymerization and the resulting pathophysiology.


An inherited disorder of red blood cells characterized by lifelong anemia and recurrent painful episodes of leukaemia is diagnosed.

Sickle cell paths converge on hydroxyurea

The realization that a mutation in a haemoglobin gene is at the root of sickle cell anaemia and the discovery of an effective treatment are separated by years. But sickle cell research is a model for

Aspartame effect in sickle cell anemia

To examine the in vitro and in vivo attributes of aspartame and to determine its efficacy for treating sickle cell anemia.



Amino-Acid Composition of Four Different Kinds of Human Hæmoglobin

The most useful method of distinguishing between these hæmoglobins is based on their different electrophoretic mobilities, while some of them also have other characteristic properties such as high resistance to alkali (F) and low solubility (B).

Sickle cell anemia a molecular disease.

The erythrocytes of certain individuals possess the capacity to undergo reversible changes in shape in response to changes in the partial pressure of oxygen, and these cells change their forms from the normal biconcave disk to crescent, holly wreath, and other forms.

The Inheritance of Sickle Cell Anemia.

The ability of the red cells to sickle was observed to have a genetic basis not long after sickle cell anemia, and this hypothesis has a counterpart in the relationship which has been demonstrated to exist between thalassemia major and minor.

The free amino groups of haemoglobins.

It is recommended that the proteases described in this paper shall be considered identical until evidence to the contrary is adduced, and that they be called leaf proteases, adding where necessary the name of the plant.

Sulphydryl groups in haemoglobins.