A Specialist Macaque MHC Class I Molecule with HLA-B*27-like Peptide-Binding Characteristics.

@article{Groot2017ASM,
  title={A Specialist Macaque MHC Class I Molecule with HLA-B*27-like Peptide-Binding Characteristics.},
  author={Natasja G. de Groot and Corrine M. C. Heijmans and Arnoud H. de Ru and George M. C. Janssen and Jan Wouter Drijfhout and Nel Otting and Christelle Vangenot and Gaby G. M. Doxiadis and Frits Koning and Peter A. van Veelen and Ronald Bontrop},
  journal={Journal of immunology},
  year={2017},
  volume={199 10},
  pages={3679-3690}
}
In different macaque species, the MHC A2*05 gene is present in abundance, and its gene products are characterized by low cell-surface expression and a highly conserved peptide-binding cleft. We have characterized the peptide-binding motif of Mamu-A2*05:01, and elucidated the binding capacity for virus-derived peptides. The macaque A2*05 allotype prefers the… CONTINUE READING