A Spaetzle-like role for nerve growth factor β in vertebrate immunity to Staphylococcus aureus

  title={A Spaetzle-like role for nerve growth factor β in vertebrate immunity to Staphylococcus aureus},
  author={L Garnery HR Hepburn and Tomasz K. Prajsnar and Catherine Klapholz and Pablo Moreno and Catherine A Loynes and Nikolay V. Ogryzko and Karen E. Brown and Mark Schiebler and Krisztina Hegyi and Robin Antrobus and Katherine L. Hammond and John Edward Connolly and Bernardo Ochoa and Clare Bryant and Michael Otto and Bas G Surewaard and Suranjith L Seneviratne and Dorothy M. Grogono and Julien Cachat and Tor Ny and Arthur Kaser and M Estee T{\"o}r{\"o}k and Sharon J Peacock and Matthew Holden and Tom L. Blundell and Lihui Wang and Petros Ligoxygakis and Liliana Minichiello and Colin G. Woods and Simon J Foster and Stephen A Renshaw and R Andres Floto},
Many key components of innate immunity to infection are shared between Drosophila and humans. However, the fly Toll ligand Spaetzle is not thought to have a vertebrate equivalent. We have found that the structurally related cystine-knot protein, nerve growth factor β (NGFβ), plays an unexpected Spaetzle-like role in immunity to Staphylococcus aureus infection in chordates. Deleterious mutations of either human NGFβ or its high-affinity receptor tropomyosin-related kinase receptor A (TRKA) were… CONTINUE READING
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