A Soluble Form of B Cell Maturation Antigen, a Receptor for the Tumor Necrosis Factor Family Member April, Inhibits Tumor Cell Growth

@article{Rennert2000ASF,
  title={A Soluble Form of B Cell Maturation Antigen, a Receptor for the Tumor Necrosis Factor Family Member April, Inhibits Tumor Cell Growth},
  author={Paul D. Rennert and Pascal Schneider and Teresa G. Cachero and Jeffrey S. Thompson and Luciana Trabach and Sylvie Hertig and Nils Holler and Fang Qian and Colleen Mullen and Kathy Strauch and Jeffrey L. Browning and Christine Ambrose and J. -M. Tschopp},
  journal={The Journal of Experimental Medicine},
  year={2000},
  volume={192},
  pages={1677 - 1684}
}
A proliferation-inducing ligand (APRIL) is a ligand of the tumor necrosis factor (TNF) family that stimulates tumor cell growth in vitro and in vivo. Expression of APRIL is highly upregulated in many tumors including colon and prostate carcinomas. Here we identify B cell maturation antigen (BCMA) and transmembrane activator and calcium modulator and cyclophilin ligand (CAML) interactor (TACI), two predicted members of the TNF receptor family, as receptors for APRIL. APRIL binds BCMA with higher… CONTINUE READING

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