A SnoRNA-derived piRNA interacts with human interleukin-4 pre-mRNA and induces its decay in nuclear exosomes

@article{Zhong2015ASP,
  title={A SnoRNA-derived piRNA interacts with human interleukin-4 pre-mRNA and induces its decay in nuclear exosomes},
  author={Fudi Zhong and Nan Zhou and Kang Wu and Yubiao Guo and Weiping Tan and H. Zhang and Xue Zhang and Guannan Geng and T. Pan and Hai-hua Luo and Yijun Zhang and Zhibin Xu and J. Liu and B. Liu and W. Gao and Chao Liu and Lian-wei Ren and Jun Yu Li and Jie Zhou},
  journal={Nucleic Acids Research},
  year={2015},
  volume={43},
  pages={10474 - 10491}
}
PIWI interacting RNAs (piRNAs) are highly expressed in germline cells and are involved in maintaining genome integrity by silencing transposons. These are also involved in DNA/histone methylation and gene expression regulation in somatic cells of invertebrates. The functions of piRNAs in somatic cells of vertebrates, however, remain elusive. We found that snoRNA-derived and C (C′)/D′ (D)-box conserved piRNAs are abundant in human CD4 primary T-lymphocytes. piRNA (piR30840) significantly… Expand
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