A SnoN-Ccd1 pathway promotes axonal morphogenesis in the mammalian brain.

  title={A SnoN-Ccd1 pathway promotes axonal morphogenesis in the mammalian brain.},
  author={Yoshiho Ikeuchi and Judith Stegm{\"u}ller and Stuart J. Netherton and Mai Anh Huynh and Masayuki Masu and David M. Frank and Shirin Bonni and Azad Bonni},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  volume={29 13},
The transcriptional corepressor SnoN is a critical regulator of axonal morphogenesis, but how SnoN drives axonal growth is unknown. Here, we report that gene-profiling analyses in cerebellar granule neurons reveal that the large majority of genes altered upon SnoN knockdown are surprisingly downregulated, suggesting that SnoN may activate transcription in neurons. Accordingly, we find that the transcriptional coactivator p300 interacts with SnoN, and p300 plays a critical role in SnoN-induced… CONTINUE READING
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