A Smurf1 tale: function and regulation of an ubiquitin ligase in multiple cellular networks

@article{Cao2012AST,
  title={A Smurf1 tale: function and regulation of an ubiquitin ligase in multiple cellular networks},
  author={Yu Cao and Lingqiang Zhang},
  journal={Cellular and Molecular Life Sciences},
  year={2012},
  volume={70},
  pages={2305-2317}
}
Since being discovered and intensively studied for over a decade, Smad ubiquitylation regulatory factor-1 (Smurf1) has been linked with several important biological pathways, including the bone morphogenetic protein pathway, the non-canonical Wnt pathway, and the mitogen-activated protein kinase pathway. Multiple functions of this ubiquitin ligase have been discovered in cell growth and morphogenesis, cell migration, cell polarity, and autophagy. Smurf1 is related to physiological… CONTINUE READING

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