A Small Molecule β2 Integrin Agonist Improves Chronic Kidney Allograft Survival by Reducing Leukocyte Recruitment and Accompanying Vasculopathy

@inproceedings{Khan2014ASM,
  title={A Small Molecule β2 Integrin Agonist Improves Chronic Kidney Allograft Survival by Reducing Leukocyte Recruitment and Accompanying Vasculopathy},
  author={Samia Q. Khan and Lingling Guo and David J. Cimbaluk and Hatem A. Elshabrawy and Mohd Hafeez Faridi and Meenakshi Jolly and James F. George and Anupam Agarwal and Vineet Kumar Gupta},
  booktitle={Front. Med.},
  year={2014}
}
Kidney allograft rejection is associated with infiltration of inflammatory CD11b+ leukocytes. A CD11b agonist leukadherin-1 (LA1) increases leukocyte adhesion, preventing their transmigration and tissue recruitment in vivo. Here, we test the extent to which LA1-mediated activation of CD11b/CD18 enhances kidney allograft survival in a mouse model of fully MHC-mismatched orthotopic kidney transplantation, where C57BL/6J (H-2(b)) recipients received kidney allografts from Balb/c mice (H-2(d… CONTINUE READING
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