A Small Modulatory dsRNA Specifies the Fate of Adult Neural Stem Cells

  title={A Small Modulatory dsRNA Specifies the Fate of Adult Neural Stem Cells},
  author={Tomoko Kuwabara and J. Hsieh and K. Nakashima and K. Taira and F. Gage},
  • Tomoko Kuwabara, J. Hsieh, +2 authors F. Gage
  • Published 2004
  • Biology, Medicine
  • Cell
  • Discovering the molecular mechanisms that regulate neuron-specific gene expression remains a central challenge for CNS research. Here, we report that small, noncoding double-stranded (ds) RNAs play a critical role in mediating neuronal differentiation. The sequence defined by this dsRNA is NRSE/RE1, which is recognized by NRSF/REST, known primarily as a negative transcriptional regulator that restricts neuronal gene expression to neurons. The NRSE dsRNA can trigger gene expression of neuron… CONTINUE READING

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