A Small Modulatory dsRNA Specifies the Fate of Adult Neural Stem Cells

Abstract

Discovering the molecular mechanisms that regulate neuron-specific gene expression remains a central challenge for CNS research. Here, we report that small, noncoding double-stranded (ds) RNAs play a critical role in mediating neuronal differentiation. The sequence defined by this dsRNA is NRSE/RE1, which is recognized by NRSF/REST, known primarily as a… (More)
DOI: 10.1016/S0092-8674(04)00248-X

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