A Small Change Can Make a Big Difference: A Lesson from Evolocumab.

@article{Mirzaee2018ASC,
  title={A Small Change Can Make a Big Difference: A Lesson from Evolocumab.},
  author={Sam Mirzaee and Paul Min Thein and Dennis T L Wong and Arthur Nasis},
  journal={Heart, lung & circulation},
  year={2018}
}
BACKGROUND Evolocumab is an expensive proprotein convertase subtilisin/kexin type 9 (PCSK9) inhibitor which has been shown to significantly improve cardiovascular outcomes in high risk patients. METHODS This is a case study describing a stepwise approach to "PCSK9 inhibitor non-response" in a patient with familial hypercholesterolaemia. There are a few… CONTINUE READING