A Smad action turnover switch operated by WW domain readers of a phosphoserine code.

@article{Aragon2011ASA,
  title={A Smad action turnover switch operated by WW domain readers of a phosphoserine code.},
  author={E Daleen Aragon and Nina Goerner and Alexia-Ileana Zaromytidou and Qiaoran Xi and Albert Escobedo and Joan Massagu{\'e} and Maria J. Macias},
  journal={Genes & development},
  year={2011},
  volume={25 12},
  pages={1275-88}
}
When directed to the nucleus by TGF-β or BMP signals, Smad proteins undergo cyclin-dependent kinase 8/9 (CDK8/9) and glycogen synthase kinase-3 (GSK3) phosphorylations that mediate the binding of YAP and Pin1 for transcriptional action, and of ubiquitin ligases Smurf1 and Nedd4L for Smad destruction. Here we demonstrate that there is an order of events-Smad activation first and destruction later-and that it is controlled by a switch in the recognition of Smad phosphoserines by WW domains in… CONTINUE READING
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