A SmD peptide induces better antibody responses to other proteins within the small nuclear ribonucleoprotein complex than to SmD protein via intermolecular epitope spreading.

@article{Deshmukh2007ASP,
  title={A SmD peptide induces better antibody responses to other proteins within the small nuclear ribonucleoprotein complex than to SmD protein via intermolecular epitope spreading.},
  author={Umesh S. Deshmukh and Harini Bagavant and Davis L Sim and Vyankatesh J Pidiyar and Shu Man Fu},
  journal={Journal of immunology},
  year={2007},
  volume={178 4},
  pages={2565-71}
}
Autoantibody response against the small nuclear ribonucleoprotein (snRNP) complex is a characteristic feature of systemic lupus erythematosus. The current investigation was undertaken to determine whether activation of SmD-reactive T cells by synthetic peptides harboring T cell epitopes can initiate a B cell epitope spreading cascade within the snRNP complex. T cell epitopes on SmD were mapped in A/J mice and were localized to three regions on SmD, within aa 26-55, 52-69, and 86-115… CONTINUE READING

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