A Skin Cancer Virus?

@article{Viscidi2008ASC,
  title={A Skin Cancer Virus?},
  author={Raphael P. Viscidi and Keerti V. Shah},
  journal={Science},
  year={2008},
  volume={319},
  pages={1049 - 1050}
}
High-throughput DNA sequencing has identified a new human virus in a rare but aggressive form of skin cancer. 

Topics from this paper

Detection of Merkel cell polyomavirus DNA in Merkel cell carcinomas
TLDR
A new human polyomvirus, Merkel cell polyomavirus (MCV), was recently isolated from these tumours by applying digital transcriptome subtraction methodology. Expand
Merkel cell carcinoma demographics, morphology, and survival based on 3870 cases: a population based study
Background: Merkel cell carcinoma (MCC) is a rare and aggressive neuroendocrine tumor arising predominantly on sun‐exposed skin of older and usually immunosuppressed individuals.
Merkel cell carcinoma.
TLDR
The discovery of the Merkel cell polyomavirus suggests another clue to the pathogenesis of Merkel cell carcinoma, a rare, highly aggressive neuroendocrine cutaneous neoplasm with a variable clinical presentation. Expand
Prevalence of Merkel cell Polyomavirus DNA in Cutaneous Lymphomas, Pseudolymphomas, and Inflammatory Skin Diseases
TLDR
It is concluded that MCPyV DNA is infrequently, but consistently present in lesional tissue from patients with primary cutaneous lymphomas, pseudolymphomas, PLs, and inflammatory skin diseases; prevalence is in the range of 8%-17%. Expand
Neuroendocrine carcinoma of the skin (Merkel cell carcinoma): current views on pathogenesisand treatment
TLDR
Discovery of the Merkel cell polyomavirus and its association with Merkel cell carcinoma may significantly contribute to understanding of MCC pathogenesis and development of new methods of therapy. Expand
Detection of Merkel Cell Polyomavirus in Epidermodysplasia-Verruciformis-Associated Skin Neoplasms
TLDR
Both MCPyV and EV-HPV may act as synergistic oncogenic cofactors in the development of EV-associated skin neoplasms and suggests a unique susceptibility of EV patients to infections with M CPyV. Expand
Merkel cell polyomavirus in cutaneous squamous cell carcinoma of immunocompetent individuals.
TLDR
The presence of M CPyV in approximately 15% of SCCs from immunocompetent individuals warrants evaluation of MCPyV as an etiologic agent in the carcinogenesis of S CC. Expand
Rising incidence of Merkel cell carcinoma
TLDR
The staging, investigation, treatment, and follow-up of MCC in eastern Denmark, and the incidence showed that incidence rates had increased 5.4 fold over the 18 year period from 1986 until 2003, with rates highest in people over the age of 65. Expand
Inflammatory monocytes are a reservoir for Merkel cell polyomavirus.
TLDR
It is raised the possibility that MCPyV persists in inflammatory monocytes and spreads along the migration routes ofinflammatory monocytes, which points to intervention strategies to contain M CPyV. Expand
Merkel cell polyomavirus is present in common warts and carcinoma in situ of the skin.
TLDR
It is concluded that common warts and carcinomas in situ can be positive for Merkel cell polyomavirus in immunosuppressed as well as immunocompetent individuals. Expand
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Clonal Integration of a Polyomavirus in Human Merkel Cell Carcinoma
TLDR
In six of eight MCV-positive MCCs, viral DNA was integrated within the tumor genome in a clonal pattern, suggesting that MCV infection and integration preceded clonal expansion of the tumor cells, and MCV may be a contributing factor in the pathogenesis of MCC. Expand
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