A SirT'N repression for Notch.


Mulligan et al. (2011) show here that the NAD(+)-dependent SIRT1 (H4K16; H1K26) deacetylase acts in concert with the LSD1 (H3K4) demethylase to repress Notch-induced transcription, thus coupling two distinct histone modifications at a key epigenetic switch for Notch target genes.

DOI: 10.1016/j.molcel.2011.05.017

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Cite this paper

@article{Jones2011ASR, title={A SirT'N repression for Notch.}, author={Katherine A. Jones}, journal={Molecular cell}, year={2011}, volume={42 5}, pages={559-60} }