A Single siRNA Suppresses Fatal Encephalitis Induced by Two Different Flaviviruses

@article{Kumar2006ASS,
  title={A Single siRNA Suppresses Fatal Encephalitis Induced by Two Different Flaviviruses},
  author={Priti D Kumar and Sang Kyung Lee and Premlata Shankar and Narasimhaswamy Manjunath},
  journal={PLoS Medicine},
  year={2006},
  volume={3},
  pages={649 - 688}
}
BACKGROUND Japanese encephalitis virus (JEV) and West Nile virus (WNV) are neurotropic flaviviruses that can cause acute encephalitis with a high fatality rate. Currently there is no effective treatment for these infections. METHODS AND FINDINGS We tested RNA interference (RNAi)-based intervention to suppress lethal JE and WN encephalitis in mice. To induce RNAi, we used either lentivirally expressed short hairpin RNA (shRNA) or synthetic short interfering RNA (siRNA). As target, we selected… CONTINUE READING