A Single Subset of Dendritic Cells Controls the Cytokine Bias of Natural Killer T Cell Responses to Diverse Glycolipid Antigens

@inproceedings{Arora2014ASS,
  title={A Single Subset of Dendritic Cells Controls the Cytokine Bias of Natural Killer T Cell Responses to Diverse Glycolipid Antigens},
  author={Pooja Arora and Andr{\'e}s Baena and Karl O. A. Yu and Neeraj Saini and Shalu Sharma Kharkwal and Michael F. Goldberg and Shajo Kunnath-Velayudhan and Leandro J Carre{\~n}o and Manjunatha Muniswamappa Venkataswamy and J J Kim and Eszter L{\'a}z{\'a}r-Moln{\'a}r and Gr{\'e}goire Lauvau and Young Tae Chang and Zheng Xia Liu and Robert Bittman and Aymen Al-Shamkhani and Liam R Cox and Peter J. Jervis and Natacha Veerapen and Gurdyal S Besra and Steven A. Porcelli},
  booktitle={Immunity},
  year={2014}
}
Many hematopoietic cell types express CD1d and are capable of presenting glycolipid antigens to invariant natural killer T cells (iNKT cells). However, the question of which cells are the principal presenters of glycolipid antigens in vivo remains controversial, and it has been suggested that this might vary depending on the structure of a particular glycolipid antigen. Here we have shown that a single type of cell, the CD8α(+) DEC-205(+) dendritic cell, was mainly responsible for capturing and… CONTINUE READING
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