A Single Nucleotide Polymorphism in Human APOBEC3C Enhances Restriction of Lentiviruses

@inproceedings{Wittkopp2016ASN,
  title={A Single Nucleotide Polymorphism in Human APOBEC3C Enhances Restriction of Lentiviruses},
  author={Cristina J. Wittkopp and Madison B. Adolph and Lily I. Wu and Linda Chelico and Michael Emerman},
  booktitle={PLoS pathogens},
  year={2016}
}
Humans express seven human APOBEC3 proteins, which can inhibit viruses and endogenous retroelements through cytidine deaminase activity. The seven paralogs differ in the potency of their antiviral effects, as well as in their antiviral targets. One APOBEC3, APOBEC3C, is exceptional as it has been found to only weakly block viruses and endogenous retroelements compared to other APOBEC3s. However, our positive selection analyses suggest that APOBEC3C has played a role in pathogen defense during… CONTINUE READING
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