A Single Mutation in Chinese Hamster Ovary Cells Both Golgi and Endosomal Functions Impairs

@inproceedings{Robbins1984ASM,
  title={A Single Mutation in Chinese Hamster Ovary Cells Both Golgi and Endosomal Functions Impairs},
  author={April R. Robbins and Constance Oliver and Judith L. Bateman and Sharon S. Krag and Cynthia J. Galloway and Ira Mellman},
  year={1984}
}
A Chinese hamster ovary cell mutant DTG 1-5-4, was selected for pleiotropic defects in receptor-mediated endocytosis by methods previously described (Robbins, A. R., S. S. Peng, and J. L. Marshall, 1983, J. Cell Biol., 96:1064-1071). DTG 1-5-4 exhibited increased resistance to modeccin, Pseudomonas toxin, diphtheria toxin, Sindbis virus, and vesicular stomatitis virus, as well as decreased uptake via the mannose 6-phosphate receptor. Fluores- cein-dextran-labeled endosomes isolated from DTG 1-5… CONTINUE READING

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