A Single Methylene Group in Oligoalkylamine-Based Cationic Polymers and Lipids Promotes Enhanced mRNA Delivery.

@article{Jarzbiska2016ASM,
  title={A Single Methylene Group in Oligoalkylamine-Based Cationic Polymers and Lipids Promotes Enhanced mRNA Delivery.},
  author={Anita Jarzębińska and Tamara Pasewald and Jana Lambrecht and Olga M. Mykhaylyk and Linda K{\"u}mmerling and Philipp Beck and Guenther Hasenpusch and Carsten Rudolph and Christian Plank and Christian Dohmen},
  journal={Angewandte Chemie},
  year={2016},
  volume={55 33},
  pages={
          9591-5
        }
}
The development of chemically modified mRNA holds great promise as a new class of biologic therapeutics. However, the intracellular delivery and endosomal escape of mRNA encapsulated in nanoparticles has not been systematically investigated. Here, we synthesized a diverse set of cationic polymers and lipids from a series of oligoalkylamines and subsequently characterized their mRNA delivery capability. Notably, a structure with an alternating alkyl chain length between amines showed the highest… CONTINUE READING
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