A Single Kinase Generates the Majority of the Secreted Phosphoproteome

  title={A Single Kinase Generates the Majority of the Secreted Phosphoproteome},
  author={Vincent S. Tagliabracci and Sandra E. Wiley and Xiao Guo and Lisa N. Kinch and Eric S Durrant and Jianzhong Wen and Junyu Xiao and Jixin Cui and Kim B. Nguyen and James L. Engel and Joshua J. Coon and Nick V. Grishin and Lorenzo A Pinna and David J Pagliarini and Jack E. Dixon},
The existence of extracellular phosphoproteins has been acknowledged for over a century. However, research in this area has been undeveloped largely because the kinases that phosphorylate secreted proteins have escaped identification. Fam20C is a kinase that phosphorylates S-x-E/pS motifs on proteins in milk and in the extracellular matrix of bones and teeth. Here, we show that Fam20C generates the majority of the extracellular phosphoproteome. Using CRISPR/Cas9 genome editing, mass… CONTINUE READING
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