A Single Kinase Generates the Majority of the Secreted Phosphoproteome

@article{Tagliabracci2015ASK,
  title={A Single Kinase Generates the Majority of the Secreted Phosphoproteome},
  author={Vincent S. Tagliabracci and Sandra E. Wiley and Xiao Guo and Lisa N. Kinch and Eric S Durrant and Jianzhong Wen and Junyu Xiao and Jixin Cui and Kim B. Nguyen and James L. Engel and Joshua J. Coon and Nick V. Grishin and Lorenzo A Pinna and David J Pagliarini and Jack E. Dixon},
  journal={Cell},
  year={2015},
  volume={161},
  pages={1619-1632}
}
The existence of extracellular phosphoproteins has been acknowledged for over a century. However, research in this area has been undeveloped largely because the kinases that phosphorylate secreted proteins have escaped identification. Fam20C is a kinase that phosphorylates S-x-E/pS motifs on proteins in milk and in the extracellular matrix of bones and teeth. Here, we show that Fam20C generates the majority of the extracellular phosphoproteome. Using CRISPR/Cas9 genome editing, mass… CONTINUE READING
Recent Discussions
This paper has been referenced on Twitter 15 times over the past 90 days. VIEW TWEETS
36 Citations
55 References
Similar Papers

Citations

Publications citing this paper.
Showing 1-10 of 36 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 55 references

Zur Frage ob Caseı́n ein einheitlicher Stoff sei

  • O. Hammarsten
  • Hoppe Seylers Z. Physiol. Chem. 7, 227–273.
  • 1883
Highly Influential
3 Excerpts

POMKmutation in a family with congenital muscular dystrophy with merosin deficiency, hypomyelination, mild hearing deficit and intellectual disability

  • A. von Renesse, M. V. Petkova, +6 authors M. Schuelke
  • J. Med. Genet
  • 2014
1 Excerpt

Similar Papers

Loading similar papers…