A Single Intrathecal or Intraperitoneal Injection of CB2 Receptor Agonist Attenuates Bone Cancer Pain and Induces a Time-Dependent Modification of GRK2

@article{Lu2016ASI,
  title={A Single Intrathecal or Intraperitoneal Injection of CB2 Receptor Agonist Attenuates Bone Cancer Pain and Induces a Time-Dependent Modification of GRK2},
  author={Cui’e Lu and Linyu Shi and Bei Sun and Yu Zhang and Bailing Hou and Yu’e Sun and Zhengya Ma and X. P. Gu},
  journal={Cellular and Molecular Neurobiology},
  year={2016},
  volume={37},
  pages={101-109}
}
The objective of this study was to explore the potential role of G-protein-coupled receptor kinase 2 (GRK2) in the progression of cannabinoid 2 receptor (CB2) agonist-induced analgesic effects of bone cancer pain. Female Sprague–Dawley rats, weighing 160–180 g, were utilized to establish a model of bone cancer pain induced by intra-tibia inoculation of Walker 256 mammary gland carcinoma cells. JWH-015, a selective CB2 agonist, was injected intrathecally or intraperitoneally on postoperative day… CONTINUE READING

4 Figures & Tables

Connections & Topics

Mentioned Connections BETA
Moreover , spinal GRK2 was an important regulator of CB2 receptor agonist - analgesia pathway .
Moreover , spinal GRK2 was an important regulator of CB2 receptor agonist - analgesia pathway .
Moreover , spinal GRK2 was an important regulator of CB2 receptor agonist - analgesia pathway .
All Topics