A Single E627K Mutation in the PB2 Protein of H9N2 Avian Influenza Virus Increases Virulence by Inducing Higher Glucocorticoids (GCs) Level

@inproceedings{Tian2012ASE,
  title={A Single E627K Mutation in the PB2 Protein of H9N2 Avian Influenza Virus Increases Virulence by Inducing Higher Glucocorticoids (GCs) Level},
  author={Jin Tian and Wen-bao Qi and Xiaokang Li and Jun He and Peirong Jiao and Changhui Zhang and Guo-Qian Liu and Ming Xing Liao},
  booktitle={PloS one},
  year={2012}
}
While repeated infection of humans and enhanced replication and transmission in mice has attracted more attention to it, the pathogenesis of H9N2 virus was less known in mice. PB(2) residue 627 as the virulent determinant of H5N1 virus is associated with systemic infection and impaired TCR activation, but the impact of this position in H9N2 virus on the host immune response has not been evaluated. In this study, we quantified the cellular immune response to infection in the mouse lung and… CONTINUE READING
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