A Single-Cell Transcriptome Atlas of the Human Pancreas

  title={A Single-Cell Transcriptome Atlas of the Human Pancreas},
  author={Mauro J. Muraro and Gitanjali Dharmadhikari and Dominic Gr{\"u}n and Nathalie Groen and Tim Dielen and E C L Jansen and Leon van Gurp and Marten A. Engelse and Françoise Carlotti and Eelco J.P. de Koning and Alexander van Oudenaarden},
  booktitle={Cell systems},
To understand organ function, it is important to have an inventory of its cell types and of their corresponding marker genes. This is a particularly challenging task for human tissues like the pancreas, because reliable markers are limited. Hence, transcriptome-wide studies are typically done on pooled islets of Langerhans, obscuring contributions from rare cell types and of potential subpopulations. To overcome this challenge, we developed an automated platform that uses FACS, robotics, and… CONTINUE READING
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